Decisionmaking in practice: The dynamics of muddling through.

Dementia: still muddling along?

Molecular Dynamics Simulation of Water Transportation through Aquaporin-4 in Rat Brain Cells

This paper investigates the mechanism of water transportation through aquaporin-4(AQP4) of ratbrain cells by means of molecular dynamics simulation with CHARMM software. The AQP4 wasembedded into a bilayer made of Dimystroilphosphatylcholine (DMPC). The results illustrate thatwater molecules move through AQP4's channel with change of orientation of oxygen of eachwater molecule.

Fair Processes for Priority Setting: Putting Theory into Practice; Comment on “Expanded HTA: Enhancing Fairness and Legitimacy”

Embedding health technology assessment (HTA) in a fair process has great potential to capture societal values relevant to public reimbursement decisions on health technologies. However, the development of such processes for priority setting has largely been theoretical. In this paper, we provide further practical lead ways on how these processes can be implemented. We first present the misconce...

In Vivo Microscopy for Real-Time Structural and Functional Cellular Imaging

Current medical practice is moving towards more quantitative and personalized methods of diagnosis and decisionmaking. This has led to a need for more complex and detailed patient-specific digital models. The resolution at which the model is described is important and may vary from macroscopic to microscopic and even molecular scales, ideally through multiscale descriptions. As these individual...

Organ donation and the ethics of muddling through

Organ donation offers opportunities for people in critical care units to help save the lives of other patients. It is not always easy, however, to handle the transition from treating a patient to preserving a potential donor, and organ donation consistently provokes ethical questions in critical care units. What do we expect ethics to deliver? In light of a recent ethics conference in Denmark, ...